Mikel Arteta will be hoping his side can bounce back from the 2-0 defeat in Eindhoven last week and pick up an important win against FC Zurich.
Although Arsenal have already qualified for the knockout stage, a win would guarantee they finish top of the group and avoid an extra knockout round.
Arteta has made seven changes to the team that won against Nottingham Forest on Sunday
ARSENAL STARTING ELEVEN TO FACE FC ZURICH
Ramsdale; White, Holding, Gabriel, Tierney; Elneny, Lokonga; Nelson, Vieira, Jesus; Nketiah
Hein, Hilson, Cedric, Tomiyasu, Saliba, Zinchenko, Partey, Smith, Odegaard, Marquinhos, Saka, Martinelli